Archives For dietary supplements


(This blog is dedicated to the faithful readers that tweet and favorite my posts. They encourage me to keep giving and keep trying to make the world a better place. It’s my dream that everyone feel good, have great energy, and for the fabulous women to look more fabulous. )


I know Dr Oz is always talking about miracle products from remote places all over the world. They are usually expensive, in such short supply and the products on the market really don’t work. But there is one right underneath our noses. It’s been around for a long time. It’s cheap, there is an abundant supply of it, and does not require a prescription. Everyone has access to it. And there is a lot of medical data showing that it really does work. It works so well that we use it in an IV form in the hospital.


This product first came to my attention when we had a short child who was not growing properly and so the doctor ordered an IV infusion of this product even thought it can be consumed orally. After the infusion the patient had several blood draws to test for the presence of growth hormone. If the child didnot have growth hormone in her blood stream that ment she was a dwarf. I learned that day that this product released growth hormone, and I knew that growth hormone was the fountain of youth. It preserves muscle mass and neuronal mass, increases neurogenisis and boosts the immune system.


I began gathering information on this drug and the next most significant thing I discovered was that it increased nitric oxide production which was a vasodilator of the micro vascular. I thought that was significant because as we age the blood flow to the periphery is diminished. If there was a substance that increased the blood flow to the fingers, toes, facial tissue, organ microvasculature that would be awesome. And it turns out that there are studies hinting that this is occurring.


So of course I could not help myself. I had to try this miraculous product for myself. I went to the body builder’s vitamin shop and bought a large powdered drink mix containing this product. I followed the instructions on the label and took it twice a day, morning and night. I felt stronger and was able to drink wine without any health consequences. But after about a month I developed extreme sleepiness around noon and head aches which I am prone to anyhow. It was so unbearable I had to take a 30 minute nap, after which time I returned to my normal state.


I did some research and found out that a daytime nap is a side effect of growth hormone injections. I stopped taking the morning dose of it and only took it at night. I should have known not to trust the dose stated on the label. Body builders are notorious for experimenting with their bodies. That’s why they grow breasts and other weird stuff happens to them. I felt fine at the one nightly dose.


Eventually, I stopped taking it all together because I have no physical ailments. I’m in the peak of my health. Maybe if I start feeling low on energy and having aches and pains and memory loss then I will reconsider taking it again.


But beware because I haven’t told you down side of this drug. All drugs are good and bad and this drug is no exception. You’ll be totally shocked to know the down side. That will have to be in a different blog because this subject could easily turn into another book and this blog is long enough.


Another time I saw this product used in the hospital was for a woman in her 30’s who came into the ER with a stroke. She had some weird disease associated with her mitochondria and her mind was being affected. A neurologist in the ER ordered an iv of this product every 6 hours at a dose that was based on her weight.


Then I also saw this product subscribed in an oral form for a frail mentally retarded adult to “beef him up.”


Okay, Okay, I’ll tell you the name of this product. Just don’t start taking it until you read part two of this blog called the downside to arginine, a miracle product. There, now you know. It’s arginine and below is what the medical literature says about it. But still, don’t take it till you read the next blog or you could develop painful sores on your genitals. I’ll explain in the blog.


Senile dementia:Cognitive function improved with arginine treatment Improvement was not maintained after discontinuation of treatment

a) Elderly patients with cerebrovascular disease showed improvement in cognitive function after 3 months of treatment with L-arginine 1.6 grams per day (p less than 0.0001). Also, lipid peroxide levels decreased significantly (p less than 0.001). However, by 3 months after the end of treatment, cognitive function scores had returned to pretreatment values. No side effects of L-arginine were observed [20].

Nutritional support


Arginine supplementation appears to significantly increase T-cell function in immunologic responses

a) The mean total number of circulating T-cells increased 7 days postoperatively in a patient group receiving a 20 grams/day arginine-only intravenous infusion [42].

b) An arginine-supplemented enteral diet was shown to improve postoperative immunologic responses in patients with upper gastrointestinal malignancies [43]. Forty-two patients were randomized to either a diet supplemented with arginine, RNA, and omega-3 fatty acids or an isocaloric, isonitrogenous placebo diet; enteral nutrition was started on postoperative day 1 and advanced to the target goal by postoperative day 5. The number of T lymphocytes, helper T cells (CD4), activated T cells (CD3, HLA-DR), and B-lymphocytes were all significantly higher in the supplemented diet group.

c) A reduced incidence of infectious complications and shorter hospital stay were demonstrated in a multicenter trial involving early enteral feedings supplemented with arginine, nucleotides, and omega-3 fatty acids [44]. A total of 296 patients admitted to intensive care units for trauma, surgery, or sepsis, who were candidates for enteral nutrition, were randomized to either a standard enteral formula (Osmolite HN(R)) or supplemented formula (Impact(R)). Although both groups were shown to benefit from early enteral nutrition, there was a significant reduction in the frequency of acquired infections and length of hospital stay in patients who received the arginine-supplemented formula, particularly if they were septic upon initiation of enteral feedings.

Erectile dysfunction


Arginine supplementation may enhance penile blood flow

In a controlled study of dietary L-arginine supplementation, men with initially low levels of nitric oxide metabolism products experienced improved sexual function while objective measures remained unchanged

Pycnogenol and L-arginine together improved sexual function in men with confirmed erectile dysfunction (ED) for at least 3 months compared to L-arginine only

a) High doses of oral L-arginine subjectively improved sexual function in men with organic erectile dysfunction (ED) with decreased nitrite/nitrate excretion. In this double-blind study, men aged between 55 and 75 years whose symptoms were diagnosed as ED first underwent a 2-week single-blind placebo run-in and then were randomized to receive L-arginine monohydrochloride 5 grams (n=32) or placebo in identical capsules (n=18), divided in 3 doses, daily over 6 weeks. Although by study end all objective variables remained unchanged in both groups, 31% (9/29) of L-arginine-treated men reported significant improvements in sexual function in diaries compared with 12% (2/17) of placebo-treated men. Three weeks of administration of L-arginine increased levels of nitrite/nitrate in plasma and urine (p less than 0.01, both values) Initial urinary nitric oxide (NO) levels in the 9 men who reported subjective improvements in their sexual activities were significantly lower than those of other patients at baseline (p less than 0.05) and levels of urinary and plasma NO in these responders increased significantly (p less than 0.01, both measures) compared to baseline by study end. Systolic and/or diastolic blood pressure decreased by approximately 10% in supplemented patients, causing no systemic effect and requiring no interruption of the study. Tolerance of the high L-arginine dose was good. Three men withdrew from the L-arginine group because of lack of improvement during the run-in phase and 1 in the placebo group withdrew because of palpitations [25].

b) Changes in erectile function and in satisfaction with sexual life were similar during treatments with arginine and with placebo. In a crossover study, 30 men with mixed-type impotence took placebo and L-arginine 500 milligrams 3 times per day, each for 17-day intervals with a 7-day washout period between. Scores on the Koln Questionnaire of Erectile Dysfunction were notably improved for 17% during arginine treatment and for 20% during placebo treatment. Mild improvements occurred in 57% with arginine and in 43% with placebo. L-arginine is the precursor of nitric oxide (NO), a mediator of penile erection, and may possibly be beneficial in a selected group of patients [26].

Essential hypertension


Improves renal vascular resistance and renal plasma flow

a) L-arginine 500 milligrams per kilogram administered intravenously over 30 minutes increased renal plasma flow (RPF) in normotensive patients (n=30) to a greater extent than in patients who had essential hypertension with serum creatinine concentrations of less than 1.5 milligrams per deciliters (mg/dL) and glomerular filtration rate (GFR) of more than 50 milliliters per minute per 1.48 meter squared (n=32) (15.8% versus 10.1%, p less than 0.05). However, RPF decreased by 11.5% in patients with severe essential hypertension (n=7) with renal insufficiency (serum creatinine concentrations of 2.0 mg/dL or more and GFR less than 50 ml/min/1.48 m(2)). Use of L-arginine also resulted in a greater decrease in renal vascular resistance (RVR) in normotensive patients as compared to patients with essential hypertension (20.1% vs 14.3%, p less than 0.05); RVR remained unchanged in the hypertensive patients with renal insufficiency [21].

Exercise-induced angina


Intravenously administered arginine improved coronary perfusion during exercise and improved performance

a) When L-arginine was administered intravenously before exercise to 12 patients with syndrome X (angina pectoris in the presence of normal coronary arteriograms), symptom-limited-exercise time was increased and myocardial perfusion was improved in a subset of patients. The absence of response in some patients suggests that factors other than endothelial dysfunction contribute to syndrome X [9].

Female infertility; Adjunct


Addition of arginine to an ovarian stimulation protocol increased the pregnancy rate over that from the ovarian stimulation protocol alone in poor responders

In normally responding women, arginine supplementation had detrimental effects on embryo quality and pregnancy rate

a) Addition of arginine to an ovarian hyperstimulation protocol for normally responding women had detrimental effects on embryo quality and pregnancy rate. In a prospective, double-blind trial, women with tubal infertility of 2 to 6 years’ duration were randomly assigned to 2 stimulation protocols: a gonadotrophin- releasing hormone agonist (triptorelin) and pure follicle stimulating hormone (FSH), with supplemental L-arginine 16 grams/day (n=18) or with placebo (n=19). The cancellation rate due to poor response was 11% in the arginine group and 15% in the placebo group. Duration of FSH treatment was significantly longer in the placebo group (12.3 days) than in the arginine group (10.6 days) (p=0.039). On the day of human chorionic gonadotropin (HCG) administration, the number of recruited follicles was higher in the arginine group (15 vs 10, p=0.021). The number and quality of oocytes retrieved did not differ for the 2 groups. However, embryo morphology was superior in the placebo group to that in the arginine group (p=0.034). The number of embryos transferred was similar for the 2 groups, but the pregnancy rates per cycle and per embryo transferred were significantly higher in the placebo than in the arginine group (p=0.024 and p=0.019, respectively). Follicular concentration of nitrates/nitrites (increased by arginine supplementation) was inversely correlated with embryo quality (r=-0.613, p=0.005). It was speculated that nitrous oxide (NO) derivatives act as vasodilators that cause too early an increase in permeability of the follicular epithelium to plasma proteins, and that this results in the follicles being susceptible to circulating FSH and growth hormone action [37].

b) Three of 17 patients receiving arginine in addition to an ovarian stimulation regimen for in-vitro fertilization achieved pregnancy (though all resulted in pregnancy loss), compared to none of 17 receiving the ovarian stimulation regimen alone. All patients were deemed poor responders on the basis of a previous failure to achieve an adequate number of mature follicles or adequate serum estradiol levels after gonadotrophin stimulation. All patients were given daily subcutaneous gonadotrophin-releasing hormone analogue (GnRHa) 0.1 milligram from day 1 of the menstrual cycle and intramuscular pure follicle stimulating hormone (pFSH) (450 international units in the first 3 days of the menstrual cycle and then an individually assessed dosage). Half of the women were also given oral arginine 16 grams daily. The cancellation rate (i.e. the percentage of cycles in which estradiol plasma concentrations were less than 1.1 picomoles/liter and/or fewer than 3 follicles were recruited by cycle day 8) was significantly lower in the group receiving arginine than in the group receiving no arginine (11% vs 76%, p less than 0.001). The number of oocytes collected and the number of embryos transferred were significantly higher in the arginine group (p less than 0.05). Uterine and perifollicular blood flow resistances were significantly lower in the arginine-treated women at all times points tested (p less than 0.047). Plasma nitrites/nitrates were higher in the arginine group and were inversely correlated with Doppler pulsatility index, suggesting that relaxation of vascular smooth muscle of endometrial vessels may be partially mediated by nitric oxide. It was concluded that oral arginine supplementation in poor responders may improve ovarian response, endometrial receptivity, and pregnancy rate (Battaglie et al, 1999).

Growth hormone deficiency


Arginine pyroglutamate may be useful in treating children with growth retardation due to GH deficiency

a) Arginine pyroglutamate (Adjuvant; Manetti & Roberts Pharmaceutical Division, Italy) 3 g orally for three days brought about a statistically significant increase in serum growth hormone (GH)in 17 children (aged 4 to 13) with short stature. It was postulated that arginine pyroglutamate may be useful in treating children with growth retardation due to GH deficiency. No serious side effects were reported [27].

Growth hormone stimulation test


Used intravenously as as diagnostic aid to test for growth hormone deficiency [2].

a) Arginine administered intravenously is used to test for growth hormone reserve in patients with suspected growth hormone deficiency [2]. The drug may also be used as an aid to detect growth hormone deficiency in panhypopituitarism, pituitary dwarfism, chromophobe adenoma, postsurgical craniopharyngioma, hypophysectomy, pituitary trauma, acromegaly, gigantism, and problems of growth and stature [2][3][4].

b) In patients with intact pituitary function, intravenous infusion of arginine will produce a pronounced rise in plasma levels of human growth hormone, usually in the range of 10 to 30 nanograms/milliliter [2][4]. In patients with impaired pituitary function, the rise of growth hormone level will be diminished or absent (0 to 10 nanograms/milliliter increase). In general, growth hormone concentrations of 4 nanograms/milliliter or less indicate pituitary growth hormone deficiency [2].

c) Confirmation of deficiency of pituitary reserve for human growth hormone with the arginine test should be confirmed by a second test with arginine or with the insulin hypoglycemia test, with a waiting period of 1 day between tests [3]. A deficiency of pituitary reserve for human growth hormone may be confirmed with the insulin hypoglycemia test with a recommended one day wait period between tests [2].

d) Some investigators recommend the use of insulin, arginine and levodopa together in determining growth hormone deficiency in short-height patients [5]..

e) Increases in growth hormone levels with arginine are generally greater in women than in men, and greater in pregnant than in non-pregnant women. Response to arginine can be blunted in obese patients and those with hypothyroidism [6][7].

f) Glucose levels increased, followed by a delayed fall, with early hyperglycemia in 13 sexual ateliotic dwarfs (deficient in human growth hormone) compared to control patients, in response to an arginine infusion . No increases in human growth hormone were observed, which did occur in previous normal subjects. Plasma insulin concentrations increased, but only by one-half that observed in control subjects; the rise in insulin was never higher than 50 microunits/mL in dwarfs. Plasma-free fatty acids decreased, with the decrease being as great or greater than normal subjects; however, these patients failed to restore levels to normal values by 120 or 150 minutes as was observed with normal subjects. The age of the patients ranged from 15 to 72 years. Arginine was given in doses of 0.25 to 0.35 grams/pound (g/lb) body weight (20 to 30 g total). The dose was given by intravenous infusion over 30 minutes. Prior to the test, the 5 male patients were given diethylstilbestrol 2.5 milligrams (mg) twice a day for 2 days. [4][8].


Intermittent claudication


Infusions of arginine increased pain-free walking distance

a) Infusions of arginine increased pain-free walking distance and absolute walking distance in patients with intermittent claudication. Thirty-nine patients with peripheral arterial occlusive disease were randomly assigned to receive 2 infusions daily of L-arginine 8 grams (g) in 50 milliliters (mL), 2 infusions daily of prostaglandin E1 (PGE1) 40 micrograms in 50 mL, or no vasodilator treatment. Patients of all 3 groups were to maintain the same walking training 3 times per day. Active treatments were given for 3 weeks. Arginine treatment produced increases in pain-free walking distance and absolute walking distance that were significantly greater than increases with exercises alone. Increases with PGE1 were between those with arginine and placebo and not significantly different from either. Increases with arginine continued for up to 6 weeks after termination of treatment, while progress did not continue after discontinuation of PGE1. Flow-mediated femoral artery dilation increased progressively with arginine infusions (p less than 0.05 vs baseline in weeks 2 and 3), while that with PGE1 was not significantly enhanced. Pain was reduced more markedly in the arginine group (p less than 0.05). The greater improvements with arginine are thought to be due to increased production of nitric oxide, the principal mediator of flow-induced vasodilation in human peripheral conductance arteries [34].


1. Schulman SP, Becker LC, Kass DA, et al: L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA 2006; 295(1):58-64.
PubMed Abstract:…
PubMed Article:…

2. Product Information: R-Gene(R) 10 IV injection, arginine HCl 10% IV injection. Pharmacia & Upjohn Company (per Manufacturer), New York, NY, 2007.

3. Raiti S, Davis WT, & Blizzard RM: A comparison of the effects of insulin hypoglycemia and arginine infusion on release of human growth hormone. Lancet 1967; 2:1182-1183.

4. Merimee TJ, Lillicrap DA, & Rabinowitz D: Effect of arginine on serum-levels of human growth hormone. Lancet 1965; 2:668-670.

5. Rodriguez-Doreste OL: Comparative study of different tests on the secretory stimulation of growth hormone in short height patients. Rev Clin Esp 1977; 147:511-514.

6. Jaquet P, Scornavachi JC, Vague P, et al: Variations in the level of human somatotrophic hormone in the plasma during arginine testing in obesity and emaciation. Ann Endocrinol 1970; 31:80-88.

7. Treychet P: Human growth hormone (HGH) response to arginine infusion test (AIT) in eight cases of primary hypothyroidism. Radioimmunoassay of plasma HGH, thyrotropin (TSH) and insulin. Ann Endocrinol 1970; 31:68-79.

8. Merimee TJ, Burgess A, & Rabinowitz D: Influence of growth hormone in insulin secretion. Studies of growth-hormone deficient subjects. Diabetes 1967; 16:478-482.

9. Fujita H, Yamabe H, & Yokoyama M: Effect of L-arginine administration on myocardial thallium-201 perfusion during exercise in patients with angina pectoris and normal coronary angiograms. J Nucl Cardiol 2000; 7(2):97-102.

10. Blum A, Porat R, Rosenschein U, et al: Clinical and inflammatory effects of dietary L-arginine in patients with intractable angina pectoris. Am J Cardiol 1999; 83(10):1488-1490.

11. Sher GD, Ginder GD, Little J, et al: Extended therapy with intravenous arginine butyrate in patients with B-hemoglobinopathies. N Engl J Med 1995; 332:1606-1610.

12. Heys SD, Ogston K, Miller I, et al: Potentiation of the response to chemotherapy in patients with breast cancer by dietary supplementation with L-arginine: results of a randomised controlled trial. Int J Oncol 1998; 12:221-225.

13. Angdin M, Settergren G, Liska J, et al: No effect of L-arginine supplementation on pulmonary endothelial dysfunction after cardiopulmonary bypass. Acta Anaesthesiol Scand 2001; 45:441-448.

14. Loukides S, Kharitonov S, Wodehouse T, et al: Effect of arginine on mucociliary function in primary ciliary dyskinesia. Lancet 1998; 352(9125):371-371.

15. Watanabe G, Tomiyama H, & Doba N: Effects of oral administration of L-arginine on renal function in patients with heart failure. J Hypertens 2000; 18(2):229-234.

16. Bocchi EA, Vilella de Moraes A, Esteves-Filho A, et al: L-arginine reduces heart rate and improves hemodynamics in severe congestive heart failure. Clin Cardiol 2000; 23:205-210.

17. Kattwinkel J, Agus SG, Taussig LM, et al: The use of L-arginine and sodium dicarbonate in the treatment of malabsorption due to cystic fibrosis. Pediatrics 1972; 50:133-137.

18. Solomons CC, Cotton EK, & Dubois R: The use of buffered L-arginine in the treatment of cystic fibrosis. Pediatrics 1971; 47:384-390.

19. Dietzsch HJ, Gottschalk B, Heyne K, et al: Cistic fibrosis: comparison of two mucolytic drugs for inhalation treatment (acetylcysteine and arginine hydrochloride). Pediatrics 1975; 55:96.

20. Ohtsuka Y & Nakaya J: Effect of oral administratin of L-arginine on senile dementia (letter). Am J Med 2000; 108:439.

21. Higashi Y, Oshima T, Ozono R, et al: Effect of L-arginine infusion on systemic and renal hemodynamics in hypertensive patients. Am J Hypertens 1999; 12:8-15.

22. Chowienczyk PF, Kneale BJ, Brett SE, et al: Lack of effect of vitamin E on L- arginine-responsive endothelial dysfunction in patients with mild hypercholesterolemia and coronary artery disease. Clin Sci 1998; 94:129-134.

23. Higashi Y, Oshima T, Watanabe M, et al: Renal response to L-arginine in salt- sensitive patients with essential hypertension. Hypertens 1996; 27(part 2):643-648.

24. Schulze-Neick I, Penny DJ, Rigby ML, et al: L-arginine and substance P reverse the pulmonary endothelial dysfunction caused by congenital heart surgery. Circulation 1999; 100:749-755.

25. Chen J, Wollman Y, Chernichovsky T, et al: Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study. Br J Urol 1999; 83:269-273.

26. Klotz T, Mathers MJ, Braun M, et al: Effectiveness of oral L-arginine in first-line treatment of erectile dysfunction in a controlled crossover study. Urol Int 1999; 63:220-223.

27. Vita F, Spignoli G, & Isidori A: Effects of arginine pyroglutamate (Adjuvant) on growth hormone in children. Clin Trials J 1987; 24:387-390.

28. Kanaya Y, Nakamura M, Kobayashi N, et al: Effects of L-arginine on lower limb vasodilator reserve and exercise capacity in patients with chronic heart failure. Heart 1999; 81:512-517.

29. Parsons HG, Scott RB, Pinto A, et al: Argininosuccinic aciduria: long-term treatment with arginine. J Inher Metab Dis 1987; 10:152-161.

30. Brusilow SW & Batshaw ML: Arginine therapy of argininosuccinase deficiency. Lancet 1979; 1:124-127.

31. Batshaw ML, Wachtel RC, Thomas GH, et al: Arginine-responsive asymptomatic hyperammonemia in the premature infant. J Pediatr 1984; 105:86-91.

32. Nagaya N, Uematsu M, Oya H, et al: Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am J Respir Crit Care Med 2001; 163:887-891.

33. Surdacki A, Zmudka K, Bieron K, et al: Lack of beneficial effects of L-arginine primary pulmonary hypertension. Wien Klin Wochenschr 1994; 106:521-526.

34. Boger RH, Bode-Boger SM, Thiele W, et al: Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. J Am Coll Cardiol 1998; 32(5):1336-1344.

35. Korting GE, Smith SD, Wheeler MA, et al: A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999; 161:558-565.

36. Cartledge JJ, Davies AM, & Eardley I: A randomized double-blind placebo-controlled crossover trial of the efficacy of L-arginine in the treatment of interstitial cystitis. BJU Int 2000; 85:421-426.

37. Battaglia C, Regnani G, Marsella T, et al: Adjuvant L-arginine treatment in controlled ovarian hyperstimulation: a double-blind, randomized study. Hum Reprod 2002; 17(3):659-665.

38. Staff AC, Berge L, Haugen G, et al: Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004; 83:103-107.

39. Khan F, Litchfield SJ, McLaren M, et al: Oral L-arginine supplementation and cutaneous vascular responses in patients with primary Raynaud’s phenomenon. Arthritis Rheum 1997; 40(2):352-357.

40. Khan F & Belch JJF: Skin blood flow in patients with systemic sclerosis and Raynaud’s phenomenon: effects of oral L-arginine supplementation. J Rheumatol 1999; 26:2389-2394.

41. Baldini G, Alabiso V, & Paolinelli C: Clinical evaluation of the treatment of recurrent infections of the respiratory tract in paediatrics by the association arginine-lysine pyrrolidon carboxylate. Clin Trials J 1987; 24:391-403.

42. Sigal RK, Shou J, & Dayl JM: Parenteral arginine infusion in humans: nutrient substrate or pharmacologic agent?. J Parent Enter Nutr 1992; 16:423-428.

43. Kemen M, Senkal M, Homan H-H, et al: Early postoperative enteral nutrition with arginine-omega-3 fatty acids and ribonucleic acid-supplemented diet versus placebo in cancer patients: an immunologic evaluation of Impact(R). Crit Care Med 1995; 23:652-659.

44. Bower RH, Cerra FB, Bershadsky B, et al: Early enteral administration of a formula (Impact(R)) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients: results of a multicenter, prospective, randomized clinical trial. Crit Care Med 1995; 23:436-449.

45. Loney LC, Norling LL, & Robson AM: The use of arginine hydrochloride infusion to assess urinary acidification. J Pediatr 1982; 100:95-97.

46. Wallace AW, Ratcliffe MB, Galindez D, et al: L-arginine infusion dilates coronary vasculature in patients undergoing coronary bypass surgery. Anesthesiology 1999; 90:1577-1586.

47. Product Information: R-GENE(R) 10 IV injection, 10% arginine hcl IV injection. Pharmacia & Upjohn Company, Kalamazoo, MI, 2003.

48. Health Canada: Health Canada advises heart patients not to use products containing L-arginine. Health Canada. Ottawa, OntarioAvailable from URL: http://www.hc-sc…. .

49. Imler M, Ruscher H, Peter B, et al: The effect of arginine in a case of recurrent hepatic coma complicating a feminizing cortico-adrenal tumor with hepatic metastasis. Sem Hop Paris 1973; 49:3183-3190.

50. Bushinsky DA & Gennari FJ: Life-threatening hyperkalaemia with arginine. Ann Intern Med 1978; 89:632.

51. Hertz P & Richardson JA: Arginine-induced hyperkalemia in renal failure patients. Arch Intern Med 1972; 130:778-780.

52. Massara F, Cagliero E, Bisbocci D, et al: The risk of pronounced hyperkalaemia after arginine infusion in the diabetic subject. Diab Metab 1981; 7:149-153.

53. Tissot-Favre A & Brette R: Effets therapeutiques dumalate d’arginine dans les cirrhoses alcooliques. Therapie 1970; 25:629-638.

54. Kattwinkel J, Agus SG, Taussig LM, et al: The use of L-arginine and sodium dicarbonate in the treatment of malabsorption due to cystic fibrosis. Pediatrics 1972; 50:133-137.

55. Dietzsch HJ, Gottschalk B, Heyne K, et al: Cistic fibrosis: comparison of two mucolytic drugs for inhalation treatment (acetylcysteine and arginine hydrochloride). Pediatrics 1975; 55:96.

56. Paton W: L-arginine-induced hypotension. Lancet 1990; 336:1016-1017.

57. Elanjian SI: Necrosis caused by extravasation of arginine hydrochloride (letter). Ann Pharmacother 1992; 26:263.

58. Tiwary CM, Rosenbloom AL, & Julius RL: Anaphylactic reaction to arginine infusion. N Engl J Med 1973; 288:218.

59. Bushinsky DA & Gennari FJ: Life-threatening hyperkalaemia with arginine. Ann Intern Med 1978; 89:632.

60. Bode-Boger SM, Boger RH, Galland A, et al: L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship. Br J Clin Pharmacol 1998; 46:489-497.

61. Tangphao O, Grossmann M, Chalon S, et al: Pharmacokinetics of intravenous and oral L-arginine in normal volunteers. Br J Clin Pharmacol 1999; 47(3):261-266.
PubMed Abstract:…
PubMed Article:…

62. Morris SM Jr: Enzymes of arginine metabolism. J Nutr 2004; 134(10 Suppl):2743S-2747S.
PubMed Abstract:…
PubMed Article:…

63. Smith SD, Wheeler MA, Foster HE Jr, et al: Improvement in interstitial cystitis symptom scores during treatment with oral L-arginine. J Urol 1997; 158:703-708.

64. Smulders RA, Aarsen M, Teerlink T, et al: Haemodynamic and biochemical responses to L-arginine and L-lysin infusions in normal subjects: L-arginine-induced vasodilatation cannot be explained by non-specific effects of cationic amino acids. Clin Sci 1997; 92:367-374.

65. Cryer P, Jacobs L, & Daughaday W: Regulation of growth hormone and prolactin secretion in patients with acromegaly and/or excessive prolactin secretion. Mt Sinai J Med NY 1973; 40:402-413.

66. Schellong SM, Boger RH, Burchert W, et al: Dose-related effect of intravenous L-arginine on muscular blood flow of the calf in patients with peripheral vascular disease: a H(2)(15)O positron emission tomography study. Clin Sci 1997; 93:159-165.

67. Wolf A, Zalpour C, Theilmeier G, et al: Dietary L-arginine supplementation normalized platelet aggregation in hypercholesterolemic humans. J Am Coll Cardiol 1997; 29:479-485.

68. Heys SD, Segar A, Payne S, et al: Dietary supplementation with L-arginine: modulation of tumour-infiltrating lymphocytes inpatients with colorectal cancer. Br J Surg 1997; 84:238-241.

69. Paulus WJ, Kastner S, Vanderheyden M, et al: Myocardial contractile effects of L-arginine in the human allograft. J Am Coll Cardiol 1997; 29:1332-1338.

70. Tentolouris C, Tousoulis D, Toutouzas P, et al: Effects of acute L-arginine administration in coronary atherosclerosis (letter). Circulation 1999; 99(12):1648.

71. Nair NPV, Lal S, Thavundayil JX, et al: Effect of normal aging on the prolactin response to graded doses of sulpiride and to arginine. Prog Neuro-Psychopharmacol Biol Psychiat 1985; 9:633-637.

72. Gianotti L, Alexander JW, Pyles T, et al: Arginine-supplemented diets improve survival in gut-derived sepsis and peritonitis by modulating bacterial clearance: the role of nitric oxide. Ann Surg 1993; 217:644-654.

73. Loche S, Carta D, Muntoni AC, et al: Oral administration of argine enhances the growth hormone response to growth hormone releasing hormone in short children. Acta Paediatr 1993; 82:883-884.

74. Dudrick PS & Souba WW: Amino acids in surgical nutrition: principles and practice. Surg Clin North Am 1991; 71:459-476.

75. Boyd JR & Olin BR (Eds): Facts and Comparisons, Facts and Comparisons Division, JP Lippincott Co, St Louis, 1984.

76. Boger RH, Bode-Boger SM, Thiele W, et al: Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. J Am Coll Cardiol 1998; 32(5):1336-1344.

77. Rahim A, Toogood AA, & Shalet SM: The assessment of growth hormone status in normal young adult males using a variety of provocative agents. Clin Endocrinol 1996; 45:557-562.

78. Raiti S, Davis WT, & Blizzard RM: A comparison of the effects of insulin hypoglycemia and arginine infusion on release of human growth hormone. Lancet 1967; 2:1182-1183.

79. Rodriguez-Doreste OL: Comparative study of different tests on the secretory stimulation of growth hormone in short height patients. Rev Clin Esp 1977; 147:511-514.






If any pill has the potential to improve the appearance of your skin it’s going to be vitamin C….in my opinion. It is essential for collagen syntheses. Collegen is connective tissue and the substance that makes skin look plump and full. In the presence of vitamin C deficiencies people develop wounds that do no heal properly. Healing is rapidly achieved when the deficiency is corrected.


In addition to having the potential to increase the thickness of the skin, vitamin C also has the potential to unify the skin color. Some experts categorize it as a skin bleach….wikipedia.


Vitamin C is the substance that keeps fruits and vegetables from tarnishing and becoming discolored when cut open and exposed to air. It’s a complicated process called biochemistry, but basically vitamin C donates an electron to atoms and molecules in desperate need of one. And for that reason, vitamin C enhances the absorption of iron from the stomach into the blood stream. Very important for people with iron deficiency anemia and blood loss.


Vitamin E is another pill with the potent to improve the skin. Similar to vitamin C, it prevents the discoloration and deterioration of meat. It is applied to meat sold in the grocery stores and keeps the produce pink and fresh looking. Without it the meat would turn a bluish gray.


Vitamin E is also added to fish oil capsules to prevent the oil from becoming rancid.


So it may came as no surprise that many topical skin products contain vitamin C and E. And there are studies proving their goodness, especially vitamin C.


But what would happen if you took these vitamins in a pill form?


Well, there are two studies that tested both these pills together short term and the results were astounding to me. Taking a combination of both vitamin C and vitamin E supplements ORALLY 2 grams of vitamin C along with 1000 IU oral vitamin E before sun exposure, reduced skin inflammation after sun exposure.4715,4716


Could these pills prevent photo aging? Possibly, since the main source of skin damage is from the sun, it makes sense, but I wouldn’t use these pills in place of sunscreen.


However, there are some commercially available products on the market that claim to be sunscreen in a pill. Basically they are combinations of vitamins C, E and A. If you don’t know it yet, vitamin A is dangerous and should only be prescribed by an eye doctor or skin doctor because it caused cancer in smokers. However, it is good for the skin and eyes. That’s another blog….subscribe and I’ll explain later.


There is also a new an antioxidant pill made from a fern that protects from the sun. It’s called Heliocare and we are still discovering how it works and what side effects it has.


But I would caution people that these pills have consequences. Vitamin C in high doses can cause nausea, vomiting, diarrhea and kidney stones. Vitamin E has been linked to an increase in prostate cancer and hemorrhagic strokes. But lots of people are willing to take their chances in pursuit of beauty, and I totally understand that. If you’re that kind of person you might also want to look into DHEA. DHEA is a pill and has been studied in relation to improving the skin and I will reveal those studies in a future blog along with much more. Stay tuned. Subscribe!



Topical Vitamin C: Traikovich SS. Use of topical ascorbic acid and its effects on photodamaged skin topography. Arch Otolaryngol Head Neck Surg. 1999;125:1091-1098.



Fuchs J, Kern H. Modulation of UV-light-induced skin inflammation by D-alpha-tocopherol and L-ascorbic acid: a clinical study using solar simulated radiation. Free Radic Biol Med 1998;25:1006-


Eberlein-Konig B, Placzek M, Przybilla B. Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alpha-tocopherol (vitamin E). J Am Acad Dermatol 1998;38:45-






How to “Boost” your immune system and avoid the need for antibiotics

Recently there has been a lot of talk in the literature about using antibiotics only when absolutely necessary. If used excessively antibiotics cause severe and dangerous diarrhea and fungal/yeast infections throughout the body. Bacteria can also become resistant to the antibiotic and therefore render it useless.

One thing we can do to avoid the need for antibiotics is to make our bodies as strong as possible and therefore resistant to opportunistic infections. We can do that by getting enough sleep, eating fruits and vegetables high in vitamin C and antioxidants (it’s not the same from pills) and not abusing our bodies with drugs and alcohol. We also need to be careful not to expose ourselves to unnecessary germs when possible. Washing hands often and wearing a mask in high-risk situations can help.

But as a pharmacist I know a few tricks of the trade to reduce infections. One of these tricks is to take vitamin C tablets when our bodies are under stress from too much exercising, from flying in an airplane, from lack of sleep or whatever. Vitamin C doesn’t seem to help much when taken every single day in high doses, although an orange a day works wonders. Save the vitamin C supplements for special occasions.

Another trick is to take certain probiotics. There are numerous studies in the literature of probiotics reducing the rate of cold and flu infections. One study gave probiotics to children ages 3-5 years old who were in daycare and exposed to recurrent colds and flu. The children who took the probiotics had fewer colds of shorter duration. Leyer 2009

The name brand yogurt used in this study is called Howaru protect.

Other studies of probiotics that work similarly do not have commercially available products that we can buy at the store. Berggren 2011

Howaru protect is the only product I know of at this point in time that is on the market and proven to boost the immune system in a medical study. This is good to know because probiotics are NOT interchangeable. You cannot substitute a generic brand and expect the same results. But rest assure I’m on the look-out for more products becoming available so stay tuned.

To save money and still use expensive probiotics judicially I’d recommend making your own healthy yogurt by using the store bought yogurt as a starter. You can google to process.

Other products that can SIGNIFICANTLY reduce the rate of lung infections are the drugs….singulair, accolate, and zyflo. These products are life changing for people with asthma and similar conditions. These drugs require a prescription so you’ll have to ask your doctor if these drugs are right for you.

To shorten the duration of the flu you can try zinc supplements, but I don’t use them and the medical studies don’t impress me. I feel that minerals are dangerous in excess and there are implications for high dose zinc that we haven’t yet found out about. But restoring a zinc deficiency does save lives in third-world countries where children would normally die at a high rate from pneumonias and diarrhea. That’s how zinc got started, but I’m not sure its goodness extends to healthy, well-nourished people in developed countries.

Echinacea is another product I do NOT recommend because it is not tested to be safe or effective. It could be grass clippings and no one would know the difference. Even if you bought it from a reputable company there are too many variables. Is it the leaves, stems, roots, or flowers that have the active ingredient? And which species? There are several different varieties. The choices are too many to confirm with medical studies.

Another way to avoid infections is to get vaccinated. Vaccines are good for a society as a whole and the negative side effects do not out number the good benefits. I know there is a lot of controversy surrounding this issue, but the fact is vaccines have eliminated fatal and crippling diseases like polio, measles, pertussis, rubella, diptheria, and mumps.

If you get the flu despite all these measures… the best thing to do is take comfort measures and wait for symptoms to pass. Tylenol, motrin, decongestants, nasal sprays, warm salt water, and throat lozenges do wonders. (However, I’d avoid corticosteroid nose sprays like Nasacort because you can develop a bacterial sinus infection as a result of using them in the presence of a viral infection like the flu. I know it sounds complicated….just don’t do it.)

The cheapest and most effective thing you can do to get well fast is drink lots of fluid. In the hospital it’s amazing what a simple IV infusion of inert water can do. It’s nothing special and the same results can be obtained from drinking a lot of fluids. It really does make a difference. You might want to put yourself on a schedule of 8 ounces every two hours. That’s equivalent to an IV infusion at 120 ml/hr which is standard.

It really is true that antibiotics do nothing to reduce the symptoms of the common cold. (Cochrane Database Syst Rev 2013 Jun 4;(6):CD000247)

Now if that isn’t enough information to process, you can read a blog on clearing up minor skin infections before they become ragging skin infections. And after that blog you will have all my drug secretes on dealing with the malevolent little bacteria.


Sexy Salad Recipe:

Ask any doctor what would happen if you ate this recipe everyday. I know…. and that’s why I call it sexy salad. This recipe, which I came up with on my own, is so versatile you can eat it everyday for the rest of your life and never grow tired of it.

  • 5 cups      of greens: spinach, romaine lettuce, spring mix greens, (broccoli bite      sized bunches)…anything of this nature.
  • 1/2      cup of unsalted nuts, any kind: pine nuts, pecans, walnuts, slivered      almonds, peanuts, sunflower seeds…
  • 1/2      cup cheese: feta, blue, mozzarella, soft balls of goat cheese.
  • 1 cup      fruit, any kind: berries, cantaloupe cubes, canned pears, canned baby      oranges,
  • 2      Tablespoons red onions chopped finely
  • splash      of olive oil and balsamic vinegar.
  • Optional:      increase the wow! factor by adding fresh herbs like cilantro, dill,      parsley, mint, chili flakes.
  • Optional:      increase the protein power add grilled chicken breast chopped into 1 inch      squares, chopped deli meats, canned chicken, black beans or garbanzo      beans.

Soak the greens in cold water for about 1 minute, spin dry in a salad spinner.  Do the same for the fresh herbs if using them.  Wash fresh fruit before cutting into bite sized pieces.  Coarsely chop nuts, toss all ingredients together and eat with a side of lean chicken or fish or by itself.



Recipe Examples:

5 cups spring mix lettuce

1/2 cup goat feta cheese

1/2 cup of pecans

1 cup black berries

2 TBSP copped red onion

Big splash of olive oil and balsamic vinegar




5 cups spinach lettuce

1 cup cantaloupe cut into 1 inch cubes

1/2 cup gorgonzola blue cheese

2 TBSP onion

1/2 cup of garbanzo beans

big splash of olive oil and balsamic vinegar

2 grilled, skinless chicken breasts cut into 1 inch cubes

1/2 cup bite size pieces of fresh dill




5 cups romaine lettuce

1 cup pears cut into bite size pieces (if fresh not available okay to use canned)

2 TBSP red onions

1/2 cup pine nuts

1/2 cup fresh mozzarella cheese

Big splash of olive oil and balsamic vinegar




.5 cups spring mixture found in grocery stores

1 cup of bite sized pieces of mangoes

1/2 cup slivered almonds

2 TBSP chopped red onions

1/2 cup fresh mozzarella

Big splash of olive oil and balsamic vinegar




1 can of tuna

5 cups broccoli cut into bite sized bunches

1 cup cranberries, dried

2 TBSP red onion

1/2 cup soy nuts

omit the cheese

Big splash of olive oil and balsamic vinegar



Get it? There’s a pattern to making sexy salad.


It’s gluten free and some doctors are finding it is anti-inflammatory in some people. It also can be lactose free if you use goat cheese or lactose free cheese. Lactose is also an allergen for some people.


Some doctors don’t recommend a lowfat diet. Instead they recommend an oil change from bad processed trans fats to omega-3 rich olive oil.  The benefits of olive oil are so numerous they include reducing and preventing arteriosclerosis, heart disease, cancer and high blood sugar and is a main staple in the healthy Mediterranean diet.


But as far as the other ingredients are concerned, nuts contain protein, phytonutrients and antioxidants such as Vitamin E and selenium. People with NATRALLY high levels of vitamin E and Selenium have healthier harts and veins, but when taken synthetically bad things can happen  ttp://


Onions have quercetin in them which is a flavinoid, vitamin B6, and chromium. They are beneficial to gastrointestinal health and cardiovascular health. Vitamin B’s lower homocysteine levels and NATRALLY low levels are a marker of good health (high homocysteine is a marker of bad health.)  They also contain allyl propyl disulfide and chromium, both of which stabilize blood sugar and detoxify the body.


And what does the lettuce and other fruits and vegetables have? Answer: so much goodness it would fill a whole book.  Basically every fresh fruit and vegetable is loaded with age fighting nutrients and if you buy organic produce grown in the USA you can’t go wrong. But it is better to buy a NONorganic vegetable than no vegetable at all.


So… I enticing you to eat healthy?

Here’s proof that I really do like dietary supplements….the right ones

Forever Young & Healthy


There are at least 16 dietary products that are so powerful we use them in the hospital. 15 of them we use in the IV formulation as well as the oral form. Over time I will talk about each and every one in detail. I was inspired to do this after I learned of articles bashing vitamins, minerals, and dietary supplements.

Product number one: magnesium. This mineral saves lives. When someone goes unconscious and we don’t know why…we go running to them with lifesaving drugs. Magnesium is one of those drugs, although it is actually a mineral. We use it commonly on the cardiac units for life threatening conditions such as irregular heart rhythms, open heart surgeries, Torsades de pointes and mitral valve prolapse

On the maternity ward it is used to save the lives of mother and baby in preterm labor. It’s sort of like a muscle relaxer and it relaxes the contracting uterus. It also relaxes the muscles in the…

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The Vitamin Concept

January 16, 2014 — 2 Comments


Some people say vitamins are a waste of money and healthy people don’t need vitamins to stay healthy. Other people say you can prevent certain cancers and cardio vascular disease with specific supplements regardless of your health. These groups hold two polar opposite views and nothing will make them agree. They are worse than democrats and republicans. They will even read the same study and come to two different conclusion. Even if the facts are undeniably against their cause they will claim that the study was a poorly designed and had weak evidence. So where does that leave us, the general public? Here’s what I say after 20 years of looking this stuff up, reading news letters, listening to lectures and trying to provide my patients with the best information possible.

A multivitamin will extend your life if you are malnourished, (references for all will be provided in the book). Vitamin D3 will extend your life if your levels are low. Vitamin C will help a wound heal if you’re deficient in vitamin C. Zinc increased the survival rate of children in third world countries, but only because they were deficient in zinc and that made them susceptible to pneumonia, other infections and severe diarrhea. Calcium will strengthen your bones if you are deficient in calcium, but does nothing to reduce fractures if you are well nourished. Iron will give you energy only if you are deficient in iron, otherwise it harms you. It’s the same concept with selenium, zinc, silver and all the other metals. The list goes on and on. In general it seems that whoever came up with the minimum daily requirements for vitamins got it right.  The recommended daily allowance (RDA) is the amount needed to prevent disease.  deficiency equals disease and vitamins have the amazing power to restore your health and keep you healthy if you have a poor diet or malabsorption problems.

However, we have to be careful not to think that if a little is good, then a lot is really good. That is a dangerous misconception. For example, if we get too much sugar in our system is that good?  After all LOW sugar is bad really bad.  People go into seizures and die when their blood sugars get too low. But high blood sugar is also really bad.  There has to be a perfect middle range.

Is that how it is with vitamins and minerals?  That is the way it is with food, water, oxygen, and sunshine. Is that a law of nature?  Possibly.

Some researchers have now come up with safe upper limits to vitamins. In a future blog and in my book I will discuss vitamins and minerals that can harm you if not taken properly. I will also tell you which vitamin deficiencies are the most common here in the USA and which deficiencies mimics normal signs of aging, but can be reversed with vitamins.


There are at least 16 dietary products that are so powerful we use them in the hospital. 15 of them we use in the IV formulation as well as the oral form. Over time I will talk about each and every one in detail. I was inspired to do this after I learned of articles bashing vitamins, minerals, and dietary supplements.

Product number one: magnesium. This mineral saves lives. When someone goes unconscious and we don’t know why…we go running to them with lifesaving drugs. Magnesium is one of those drugs, although it is actually a mineral. We use it commonly on the cardiac units for life threatening conditions such as irregular heart rhythms, open heart surgeries, Torsades de pointes and mitral valve prolapse

On the maternity ward it is used to save the lives of mother and baby in preterm labor. It’s sort of like a muscle relaxer and it relaxes the contracting uterus. It also relaxes the muscles in the blood vessels and is used for hypertension and migraines prevention. It’s used for throat spams and other spasticity’s.

It helps regulate other minerals in the body and is used to prevent the formation of kidney stones and osteoarthritis. It’s used in combination with other drugs to partially restore the brain in Wernicke’s disease (also known as wet brain, Korsakoff’s psychosis, and alcoholic encephalopathy.)

This mineral has been used for improving postoperative pain, Detrsor instability of bladder, diabetes type 2, hypercholesterolemia, Hyperphosphatemia. It prevents low potassium in combination with potassium, and reverses magnesium deficiency. It has even been studied in wound healing.

Magnesium is used for so many conditions that we restore everyone’s levels to normal. Things just run smoothly when we do.

One time I went into a patient’s room to ask a question about his home medications and he asked me….”What did you give that made me breathe so much easier?” He was slowly dying of ALS and the drug we used was iv magnesium. I explained to him that he can take it orally at home, but one of the side effects when taken orally is diarrhea. He said he suffered from chronic constipation and would use it to stay regular. He had normal kidney function so I gave him the thumbs up.

Milk of Magnesia is the drug of choice at the hospital I work at for constipation and dyspepsia. Yes you heard right, we use milk-of-magnesium for heartburn and an upset stomach….because it’s something our patients need anyhow….except for patients with kidney dysfunction. Magnesium can quickly accumulate to dangerous levels in people who do not have good kidneys. But it does not harm the kidney. It just simply can not leave the body in the presence of kidney dysfunction.

Now let me drop a bomb on you: Epson salt is magnesium sulfate. Magnesium can also be absorbed through the skin and so there is some truth to grandmas recommendation to take a hot bath in Epson salt when you are not feeling well.

And what do you suppose would happen if you drank Epsom salt? Well, if you didn’t gag from the taste, then any of the good things listed above could happen. Read the label on plain Epson salt and you will see directions for oral consumption. It’s the cheapest form of magnesium I know of.

The most interesting use for magnesium, in my opinion, is for energy and it’s often put in energy drinks.  Eight of 16 healthy male college students were given 4 bottles per day of a beverage containing Mg 25 milligrams (mg) and calcium 50 mg per bottle; the remaining 8 students served as untreated controls. All subjects underwent less than 60% of the usual amount of sleep for one month. The anaerobic threshold (physical exhaustion and muscle pain) and time to reach AT were the same in the chronically sleep-deprived state and the normal state in the Mg-treated group. In the control group, both AT and time to reach AT declined significantly during sleep deprivation (p less than 0.01 for both). Likewise, peak oxygen uptake and peak exercise time declined significantly during sleep deprivation in the control group (p less than 0.01) but were unchanged in the Mg-treated group.

Just to let you know, p value tells you if the number of people studied was large enough to wash out the possibility that the differences that occurred were by chance. It answers the question “did some freakishly strong athlete or some genetic-mutation-of-a-person in one group or the other mess up the data?” When the p-value turns out to be less than a certain significance level, often 0.05 or 0.01 it means the observation is highly unlikely to be the result of random chance alone.

In another small study 25 males took 17 millimoles magnesium orotate per day or placebo for the 4 weeks prior to a triathlon. They had better performance times than did those who took placebo. (500 meters swimming, 20 kilometers bicycle racing, and 5 kilometers running). Swimming time was significantly lower (p=0.025) for the magnesium orotate group. The increase in blood glucose during the test was significantly higher in the placebo group than in the magnesium orotate group (187% vs 118%, p less than 0.001). In the magnesium orotate group, serum insulin during the test decreased to 65% of baseline values while it increased to 139% in the placebo group (p less than 0.021). These values suggest that magnesium orotate improved insulin sensitivity. Plasma magnesium concentration was unchanged in both groups, but erythrocyte magnesium increased in the magnesium orotate group and decreased in the placebo group. While the changes from baseline were not significant for either group, the difference in concentrations of the 2 groups was significant (p=0.045).

And when looking at exercise tolerance for patients with heart disease, fourteen patients were given magnesium orotate or placebo for 4 weeks. Compared to baseline values, left ventricular end-systolic volume at 4 weeks was significantly reduced (p=0.016) and ejection fraction increased (p=0.035) in the magnesium orotate group. Changes in left ventricular end-diastolic volume and stroke volume were not significant. There were no significant changes in the echocardiographic parameters in the placebo group. An increase in exercise duration was not significant for the placebo group (p=0.21) but was significant for the magnesium orotate group (18.0 to 22.6 minutes, p=0.011) (Geiss et al, 1998). Functional capacity, as measured by metabolic equivalents and exercise duration, was greater in coronary artery disease (CAD) patients with higher intracellular magnesium (Mg(i), measured in mononuclear cells). After adjustments for age, body mass index, and systolic blood pressure at maximal exercise, Mg(i) remained a strong predictor of exercise duration. There was no difference in mean serum Mg between the group of patients with normal or below-normal Mg(i) (n=29) and the group with above-normal Mg(i) (n=13).


So who is at risk of developing a magnesium deficiency?


Those with stomach or malabsorption problems, alcoholics, people with celiac disease, chrones disease, ulcerative colitis, weigh loss surgery patents, vegitarians, and picky eaters and people over 50. But also healthy people on medications. Medications taken for years can cause magnesium deficiency over time. This is especially true with the heart burn medications called PPI’s. And example of that would be Nexium, Prilosec, Protonix, etc..
So how do you protect yourself from this deficiency? Google foods high in magnesium and consume them every day. Your body takes what it needs from food when you are healthy.
Be healthy, be strong, and live while you are alive!