Vitamin MakeOver

August 25, 2014 — Leave a comment

This is what I’m going to do for the people who call my blog talk radio show.

Forever Young & Healthy

ImageVitamin MakeOver:


DS is a 51 yr old male who took several pills because he heard they were good for him. He has no medical knowledge. This is what he put himself on: high dose vitamin C, vitamin b complex, calcium, multivitamin, arthritis herbal cocktail, magnesium, vitamin D, co-enzyme Q10, l-carnitine, d-ribose, fish oil. His doctor put him on Nexium, an acid blocker, for barrettes disease. 


This is how I changed or reinforced his regimen:


#1, keep taking the Nexium. You may read articles on natural ways and dietary changes to help a person get off their acid reducing medications, but that does not apply to DS. Those changes are only for people with bad diets who drink too much coffee and diet cokes. They are on a downward spiral of bad consequences as a result of their diet. DS, on the other hand, will develop esophageal…

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(This blog is dedicated to the faithful readers that tweet and favorite my posts. They encourage me to keep giving and keep trying to make the world a better place. It’s my dream that everyone feel good, have great energy, and for the fabulous women to look more fabulous. )


I know Dr Oz is always talking about miracle products from remote places all over the world. They are usually expensive, in such short supply and the products on the market really don’t work. But there is one right underneath our noses. It’s been around for a long time. It’s cheap, there is an abundant supply of it, and does not require a prescription. Everyone has access to it. And there is a lot of medical data showing that it really does work. It works so well that we use it in an IV form in the hospital.


This product first came to my attention when we had a short child who was not growing properly and so the doctor ordered an IV infusion of this product even thought it can be consumed orally. After the infusion the patient had several blood draws to test for the presence of growth hormone. If the child didnot have growth hormone in her blood stream that ment she was a dwarf. I learned that day that this product released growth hormone, and I knew that growth hormone was the fountain of youth. It preserves muscle mass and neuronal mass, increases neurogenisis and boosts the immune system.


I began gathering information on this drug and the next most significant thing I discovered was that it increased nitric oxide production which was a vasodilator of the micro vascular. I thought that was significant because as we age the blood flow to the periphery is diminished. If there was a substance that increased the blood flow to the fingers, toes, facial tissue, organ microvasculature that would be awesome. And it turns out that there are studies hinting that this is occurring.


So of course I could not help myself. I had to try this miraculous product for myself. I went to the body builder’s vitamin shop and bought a large powdered drink mix containing this product. I followed the instructions on the label and took it twice a day, morning and night. I felt stronger and was able to drink wine without any health consequences. But after about a month I developed extreme sleepiness around noon and head aches which I am prone to anyhow. It was so unbearable I had to take a 30 minute nap, after which time I returned to my normal state.


I did some research and found out that a daytime nap is a side effect of growth hormone injections. I stopped taking the morning dose of it and only took it at night. I should have known not to trust the dose stated on the label. Body builders are notorious for experimenting with their bodies. That’s why they grow breasts and other weird stuff happens to them. I felt fine at the one nightly dose.


Eventually, I stopped taking it all together because I have no physical ailments. I’m in the peak of my health. Maybe if I start feeling low on energy and having aches and pains and memory loss then I will reconsider taking it again.


But beware because I haven’t told you down side of this drug. All drugs are good and bad and this drug is no exception. You’ll be totally shocked to know the down side. That will have to be in a different blog because this subject could easily turn into another book and this blog is long enough.


Another time I saw this product used in the hospital was for a woman in her 30’s who came into the ER with a stroke. She had some weird disease associated with her mitochondria and her mind was being affected. A neurologist in the ER ordered an iv of this product every 6 hours at a dose that was based on her weight.


Then I also saw this product subscribed in an oral form for a frail mentally retarded adult to “beef him up.”


Okay, Okay, I’ll tell you the name of this product. Just don’t start taking it until you read part two of this blog called the downside to arginine, a miracle product. There, now you know. It’s arginine and below is what the medical literature says about it. But still, don’t take it till you read the next blog or you could develop painful sores on your genitals. I’ll explain in the blog.


Senile dementia:Cognitive function improved with arginine treatment Improvement was not maintained after discontinuation of treatment

a) Elderly patients with cerebrovascular disease showed improvement in cognitive function after 3 months of treatment with L-arginine 1.6 grams per day (p less than 0.0001). Also, lipid peroxide levels decreased significantly (p less than 0.001). However, by 3 months after the end of treatment, cognitive function scores had returned to pretreatment values. No side effects of L-arginine were observed [20].

Nutritional support


Arginine supplementation appears to significantly increase T-cell function in immunologic responses

a) The mean total number of circulating T-cells increased 7 days postoperatively in a patient group receiving a 20 grams/day arginine-only intravenous infusion [42].

b) An arginine-supplemented enteral diet was shown to improve postoperative immunologic responses in patients with upper gastrointestinal malignancies [43]. Forty-two patients were randomized to either a diet supplemented with arginine, RNA, and omega-3 fatty acids or an isocaloric, isonitrogenous placebo diet; enteral nutrition was started on postoperative day 1 and advanced to the target goal by postoperative day 5. The number of T lymphocytes, helper T cells (CD4), activated T cells (CD3, HLA-DR), and B-lymphocytes were all significantly higher in the supplemented diet group.

c) A reduced incidence of infectious complications and shorter hospital stay were demonstrated in a multicenter trial involving early enteral feedings supplemented with arginine, nucleotides, and omega-3 fatty acids [44]. A total of 296 patients admitted to intensive care units for trauma, surgery, or sepsis, who were candidates for enteral nutrition, were randomized to either a standard enteral formula (Osmolite HN(R)) or supplemented formula (Impact(R)). Although both groups were shown to benefit from early enteral nutrition, there was a significant reduction in the frequency of acquired infections and length of hospital stay in patients who received the arginine-supplemented formula, particularly if they were septic upon initiation of enteral feedings.

Erectile dysfunction


Arginine supplementation may enhance penile blood flow

In a controlled study of dietary L-arginine supplementation, men with initially low levels of nitric oxide metabolism products experienced improved sexual function while objective measures remained unchanged

Pycnogenol and L-arginine together improved sexual function in men with confirmed erectile dysfunction (ED) for at least 3 months compared to L-arginine only

a) High doses of oral L-arginine subjectively improved sexual function in men with organic erectile dysfunction (ED) with decreased nitrite/nitrate excretion. In this double-blind study, men aged between 55 and 75 years whose symptoms were diagnosed as ED first underwent a 2-week single-blind placebo run-in and then were randomized to receive L-arginine monohydrochloride 5 grams (n=32) or placebo in identical capsules (n=18), divided in 3 doses, daily over 6 weeks. Although by study end all objective variables remained unchanged in both groups, 31% (9/29) of L-arginine-treated men reported significant improvements in sexual function in diaries compared with 12% (2/17) of placebo-treated men. Three weeks of administration of L-arginine increased levels of nitrite/nitrate in plasma and urine (p less than 0.01, both values) Initial urinary nitric oxide (NO) levels in the 9 men who reported subjective improvements in their sexual activities were significantly lower than those of other patients at baseline (p less than 0.05) and levels of urinary and plasma NO in these responders increased significantly (p less than 0.01, both measures) compared to baseline by study end. Systolic and/or diastolic blood pressure decreased by approximately 10% in supplemented patients, causing no systemic effect and requiring no interruption of the study. Tolerance of the high L-arginine dose was good. Three men withdrew from the L-arginine group because of lack of improvement during the run-in phase and 1 in the placebo group withdrew because of palpitations [25].

b) Changes in erectile function and in satisfaction with sexual life were similar during treatments with arginine and with placebo. In a crossover study, 30 men with mixed-type impotence took placebo and L-arginine 500 milligrams 3 times per day, each for 17-day intervals with a 7-day washout period between. Scores on the Koln Questionnaire of Erectile Dysfunction were notably improved for 17% during arginine treatment and for 20% during placebo treatment. Mild improvements occurred in 57% with arginine and in 43% with placebo. L-arginine is the precursor of nitric oxide (NO), a mediator of penile erection, and may possibly be beneficial in a selected group of patients [26].

Essential hypertension


Improves renal vascular resistance and renal plasma flow

a) L-arginine 500 milligrams per kilogram administered intravenously over 30 minutes increased renal plasma flow (RPF) in normotensive patients (n=30) to a greater extent than in patients who had essential hypertension with serum creatinine concentrations of less than 1.5 milligrams per deciliters (mg/dL) and glomerular filtration rate (GFR) of more than 50 milliliters per minute per 1.48 meter squared (n=32) (15.8% versus 10.1%, p less than 0.05). However, RPF decreased by 11.5% in patients with severe essential hypertension (n=7) with renal insufficiency (serum creatinine concentrations of 2.0 mg/dL or more and GFR less than 50 ml/min/1.48 m(2)). Use of L-arginine also resulted in a greater decrease in renal vascular resistance (RVR) in normotensive patients as compared to patients with essential hypertension (20.1% vs 14.3%, p less than 0.05); RVR remained unchanged in the hypertensive patients with renal insufficiency [21].

Exercise-induced angina


Intravenously administered arginine improved coronary perfusion during exercise and improved performance

a) When L-arginine was administered intravenously before exercise to 12 patients with syndrome X (angina pectoris in the presence of normal coronary arteriograms), symptom-limited-exercise time was increased and myocardial perfusion was improved in a subset of patients. The absence of response in some patients suggests that factors other than endothelial dysfunction contribute to syndrome X [9].

Female infertility; Adjunct


Addition of arginine to an ovarian stimulation protocol increased the pregnancy rate over that from the ovarian stimulation protocol alone in poor responders

In normally responding women, arginine supplementation had detrimental effects on embryo quality and pregnancy rate

a) Addition of arginine to an ovarian hyperstimulation protocol for normally responding women had detrimental effects on embryo quality and pregnancy rate. In a prospective, double-blind trial, women with tubal infertility of 2 to 6 years’ duration were randomly assigned to 2 stimulation protocols: a gonadotrophin- releasing hormone agonist (triptorelin) and pure follicle stimulating hormone (FSH), with supplemental L-arginine 16 grams/day (n=18) or with placebo (n=19). The cancellation rate due to poor response was 11% in the arginine group and 15% in the placebo group. Duration of FSH treatment was significantly longer in the placebo group (12.3 days) than in the arginine group (10.6 days) (p=0.039). On the day of human chorionic gonadotropin (HCG) administration, the number of recruited follicles was higher in the arginine group (15 vs 10, p=0.021). The number and quality of oocytes retrieved did not differ for the 2 groups. However, embryo morphology was superior in the placebo group to that in the arginine group (p=0.034). The number of embryos transferred was similar for the 2 groups, but the pregnancy rates per cycle and per embryo transferred were significantly higher in the placebo than in the arginine group (p=0.024 and p=0.019, respectively). Follicular concentration of nitrates/nitrites (increased by arginine supplementation) was inversely correlated with embryo quality (r=-0.613, p=0.005). It was speculated that nitrous oxide (NO) derivatives act as vasodilators that cause too early an increase in permeability of the follicular epithelium to plasma proteins, and that this results in the follicles being susceptible to circulating FSH and growth hormone action [37].

b) Three of 17 patients receiving arginine in addition to an ovarian stimulation regimen for in-vitro fertilization achieved pregnancy (though all resulted in pregnancy loss), compared to none of 17 receiving the ovarian stimulation regimen alone. All patients were deemed poor responders on the basis of a previous failure to achieve an adequate number of mature follicles or adequate serum estradiol levels after gonadotrophin stimulation. All patients were given daily subcutaneous gonadotrophin-releasing hormone analogue (GnRHa) 0.1 milligram from day 1 of the menstrual cycle and intramuscular pure follicle stimulating hormone (pFSH) (450 international units in the first 3 days of the menstrual cycle and then an individually assessed dosage). Half of the women were also given oral arginine 16 grams daily. The cancellation rate (i.e. the percentage of cycles in which estradiol plasma concentrations were less than 1.1 picomoles/liter and/or fewer than 3 follicles were recruited by cycle day 8) was significantly lower in the group receiving arginine than in the group receiving no arginine (11% vs 76%, p less than 0.001). The number of oocytes collected and the number of embryos transferred were significantly higher in the arginine group (p less than 0.05). Uterine and perifollicular blood flow resistances were significantly lower in the arginine-treated women at all times points tested (p less than 0.047). Plasma nitrites/nitrates were higher in the arginine group and were inversely correlated with Doppler pulsatility index, suggesting that relaxation of vascular smooth muscle of endometrial vessels may be partially mediated by nitric oxide. It was concluded that oral arginine supplementation in poor responders may improve ovarian response, endometrial receptivity, and pregnancy rate (Battaglie et al, 1999).

Growth hormone deficiency


Arginine pyroglutamate may be useful in treating children with growth retardation due to GH deficiency

a) Arginine pyroglutamate (Adjuvant; Manetti & Roberts Pharmaceutical Division, Italy) 3 g orally for three days brought about a statistically significant increase in serum growth hormone (GH)in 17 children (aged 4 to 13) with short stature. It was postulated that arginine pyroglutamate may be useful in treating children with growth retardation due to GH deficiency. No serious side effects were reported [27].

Growth hormone stimulation test


Used intravenously as as diagnostic aid to test for growth hormone deficiency [2].

a) Arginine administered intravenously is used to test for growth hormone reserve in patients with suspected growth hormone deficiency [2]. The drug may also be used as an aid to detect growth hormone deficiency in panhypopituitarism, pituitary dwarfism, chromophobe adenoma, postsurgical craniopharyngioma, hypophysectomy, pituitary trauma, acromegaly, gigantism, and problems of growth and stature [2][3][4].

b) In patients with intact pituitary function, intravenous infusion of arginine will produce a pronounced rise in plasma levels of human growth hormone, usually in the range of 10 to 30 nanograms/milliliter [2][4]. In patients with impaired pituitary function, the rise of growth hormone level will be diminished or absent (0 to 10 nanograms/milliliter increase). In general, growth hormone concentrations of 4 nanograms/milliliter or less indicate pituitary growth hormone deficiency [2].

c) Confirmation of deficiency of pituitary reserve for human growth hormone with the arginine test should be confirmed by a second test with arginine or with the insulin hypoglycemia test, with a waiting period of 1 day between tests [3]. A deficiency of pituitary reserve for human growth hormone may be confirmed with the insulin hypoglycemia test with a recommended one day wait period between tests [2].

d) Some investigators recommend the use of insulin, arginine and levodopa together in determining growth hormone deficiency in short-height patients [5]..

e) Increases in growth hormone levels with arginine are generally greater in women than in men, and greater in pregnant than in non-pregnant women. Response to arginine can be blunted in obese patients and those with hypothyroidism [6][7].

f) Glucose levels increased, followed by a delayed fall, with early hyperglycemia in 13 sexual ateliotic dwarfs (deficient in human growth hormone) compared to control patients, in response to an arginine infusion . No increases in human growth hormone were observed, which did occur in previous normal subjects. Plasma insulin concentrations increased, but only by one-half that observed in control subjects; the rise in insulin was never higher than 50 microunits/mL in dwarfs. Plasma-free fatty acids decreased, with the decrease being as great or greater than normal subjects; however, these patients failed to restore levels to normal values by 120 or 150 minutes as was observed with normal subjects. The age of the patients ranged from 15 to 72 years. Arginine was given in doses of 0.25 to 0.35 grams/pound (g/lb) body weight (20 to 30 g total). The dose was given by intravenous infusion over 30 minutes. Prior to the test, the 5 male patients were given diethylstilbestrol 2.5 milligrams (mg) twice a day for 2 days. [4][8].


Intermittent claudication


Infusions of arginine increased pain-free walking distance

a) Infusions of arginine increased pain-free walking distance and absolute walking distance in patients with intermittent claudication. Thirty-nine patients with peripheral arterial occlusive disease were randomly assigned to receive 2 infusions daily of L-arginine 8 grams (g) in 50 milliliters (mL), 2 infusions daily of prostaglandin E1 (PGE1) 40 micrograms in 50 mL, or no vasodilator treatment. Patients of all 3 groups were to maintain the same walking training 3 times per day. Active treatments were given for 3 weeks. Arginine treatment produced increases in pain-free walking distance and absolute walking distance that were significantly greater than increases with exercises alone. Increases with PGE1 were between those with arginine and placebo and not significantly different from either. Increases with arginine continued for up to 6 weeks after termination of treatment, while progress did not continue after discontinuation of PGE1. Flow-mediated femoral artery dilation increased progressively with arginine infusions (p less than 0.05 vs baseline in weeks 2 and 3), while that with PGE1 was not significantly enhanced. Pain was reduced more markedly in the arginine group (p less than 0.05). The greater improvements with arginine are thought to be due to increased production of nitric oxide, the principal mediator of flow-induced vasodilation in human peripheral conductance arteries [34].


1. Schulman SP, Becker LC, Kass DA, et al: L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA 2006; 295(1):58-64.
PubMed Abstract:…
PubMed Article:…

2. Product Information: R-Gene(R) 10 IV injection, arginine HCl 10% IV injection. Pharmacia & Upjohn Company (per Manufacturer), New York, NY, 2007.

3. Raiti S, Davis WT, & Blizzard RM: A comparison of the effects of insulin hypoglycemia and arginine infusion on release of human growth hormone. Lancet 1967; 2:1182-1183.

4. Merimee TJ, Lillicrap DA, & Rabinowitz D: Effect of arginine on serum-levels of human growth hormone. Lancet 1965; 2:668-670.

5. Rodriguez-Doreste OL: Comparative study of different tests on the secretory stimulation of growth hormone in short height patients. Rev Clin Esp 1977; 147:511-514.

6. Jaquet P, Scornavachi JC, Vague P, et al: Variations in the level of human somatotrophic hormone in the plasma during arginine testing in obesity and emaciation. Ann Endocrinol 1970; 31:80-88.

7. Treychet P: Human growth hormone (HGH) response to arginine infusion test (AIT) in eight cases of primary hypothyroidism. Radioimmunoassay of plasma HGH, thyrotropin (TSH) and insulin. Ann Endocrinol 1970; 31:68-79.

8. Merimee TJ, Burgess A, & Rabinowitz D: Influence of growth hormone in insulin secretion. Studies of growth-hormone deficient subjects. Diabetes 1967; 16:478-482.

9. Fujita H, Yamabe H, & Yokoyama M: Effect of L-arginine administration on myocardial thallium-201 perfusion during exercise in patients with angina pectoris and normal coronary angiograms. J Nucl Cardiol 2000; 7(2):97-102.

10. Blum A, Porat R, Rosenschein U, et al: Clinical and inflammatory effects of dietary L-arginine in patients with intractable angina pectoris. Am J Cardiol 1999; 83(10):1488-1490.

11. Sher GD, Ginder GD, Little J, et al: Extended therapy with intravenous arginine butyrate in patients with B-hemoglobinopathies. N Engl J Med 1995; 332:1606-1610.

12. Heys SD, Ogston K, Miller I, et al: Potentiation of the response to chemotherapy in patients with breast cancer by dietary supplementation with L-arginine: results of a randomised controlled trial. Int J Oncol 1998; 12:221-225.

13. Angdin M, Settergren G, Liska J, et al: No effect of L-arginine supplementation on pulmonary endothelial dysfunction after cardiopulmonary bypass. Acta Anaesthesiol Scand 2001; 45:441-448.

14. Loukides S, Kharitonov S, Wodehouse T, et al: Effect of arginine on mucociliary function in primary ciliary dyskinesia. Lancet 1998; 352(9125):371-371.

15. Watanabe G, Tomiyama H, & Doba N: Effects of oral administration of L-arginine on renal function in patients with heart failure. J Hypertens 2000; 18(2):229-234.

16. Bocchi EA, Vilella de Moraes A, Esteves-Filho A, et al: L-arginine reduces heart rate and improves hemodynamics in severe congestive heart failure. Clin Cardiol 2000; 23:205-210.

17. Kattwinkel J, Agus SG, Taussig LM, et al: The use of L-arginine and sodium dicarbonate in the treatment of malabsorption due to cystic fibrosis. Pediatrics 1972; 50:133-137.

18. Solomons CC, Cotton EK, & Dubois R: The use of buffered L-arginine in the treatment of cystic fibrosis. Pediatrics 1971; 47:384-390.

19. Dietzsch HJ, Gottschalk B, Heyne K, et al: Cistic fibrosis: comparison of two mucolytic drugs for inhalation treatment (acetylcysteine and arginine hydrochloride). Pediatrics 1975; 55:96.

20. Ohtsuka Y & Nakaya J: Effect of oral administratin of L-arginine on senile dementia (letter). Am J Med 2000; 108:439.

21. Higashi Y, Oshima T, Ozono R, et al: Effect of L-arginine infusion on systemic and renal hemodynamics in hypertensive patients. Am J Hypertens 1999; 12:8-15.

22. Chowienczyk PF, Kneale BJ, Brett SE, et al: Lack of effect of vitamin E on L- arginine-responsive endothelial dysfunction in patients with mild hypercholesterolemia and coronary artery disease. Clin Sci 1998; 94:129-134.

23. Higashi Y, Oshima T, Watanabe M, et al: Renal response to L-arginine in salt- sensitive patients with essential hypertension. Hypertens 1996; 27(part 2):643-648.

24. Schulze-Neick I, Penny DJ, Rigby ML, et al: L-arginine and substance P reverse the pulmonary endothelial dysfunction caused by congenital heart surgery. Circulation 1999; 100:749-755.

25. Chen J, Wollman Y, Chernichovsky T, et al: Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study. Br J Urol 1999; 83:269-273.

26. Klotz T, Mathers MJ, Braun M, et al: Effectiveness of oral L-arginine in first-line treatment of erectile dysfunction in a controlled crossover study. Urol Int 1999; 63:220-223.

27. Vita F, Spignoli G, & Isidori A: Effects of arginine pyroglutamate (Adjuvant) on growth hormone in children. Clin Trials J 1987; 24:387-390.

28. Kanaya Y, Nakamura M, Kobayashi N, et al: Effects of L-arginine on lower limb vasodilator reserve and exercise capacity in patients with chronic heart failure. Heart 1999; 81:512-517.

29. Parsons HG, Scott RB, Pinto A, et al: Argininosuccinic aciduria: long-term treatment with arginine. J Inher Metab Dis 1987; 10:152-161.

30. Brusilow SW & Batshaw ML: Arginine therapy of argininosuccinase deficiency. Lancet 1979; 1:124-127.

31. Batshaw ML, Wachtel RC, Thomas GH, et al: Arginine-responsive asymptomatic hyperammonemia in the premature infant. J Pediatr 1984; 105:86-91.

32. Nagaya N, Uematsu M, Oya H, et al: Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am J Respir Crit Care Med 2001; 163:887-891.

33. Surdacki A, Zmudka K, Bieron K, et al: Lack of beneficial effects of L-arginine primary pulmonary hypertension. Wien Klin Wochenschr 1994; 106:521-526.

34. Boger RH, Bode-Boger SM, Thiele W, et al: Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. J Am Coll Cardiol 1998; 32(5):1336-1344.

35. Korting GE, Smith SD, Wheeler MA, et al: A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999; 161:558-565.

36. Cartledge JJ, Davies AM, & Eardley I: A randomized double-blind placebo-controlled crossover trial of the efficacy of L-arginine in the treatment of interstitial cystitis. BJU Int 2000; 85:421-426.

37. Battaglia C, Regnani G, Marsella T, et al: Adjuvant L-arginine treatment in controlled ovarian hyperstimulation: a double-blind, randomized study. Hum Reprod 2002; 17(3):659-665.

38. Staff AC, Berge L, Haugen G, et al: Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004; 83:103-107.

39. Khan F, Litchfield SJ, McLaren M, et al: Oral L-arginine supplementation and cutaneous vascular responses in patients with primary Raynaud’s phenomenon. Arthritis Rheum 1997; 40(2):352-357.

40. Khan F & Belch JJF: Skin blood flow in patients with systemic sclerosis and Raynaud’s phenomenon: effects of oral L-arginine supplementation. J Rheumatol 1999; 26:2389-2394.

41. Baldini G, Alabiso V, & Paolinelli C: Clinical evaluation of the treatment of recurrent infections of the respiratory tract in paediatrics by the association arginine-lysine pyrrolidon carboxylate. Clin Trials J 1987; 24:391-403.

42. Sigal RK, Shou J, & Dayl JM: Parenteral arginine infusion in humans: nutrient substrate or pharmacologic agent?. J Parent Enter Nutr 1992; 16:423-428.

43. Kemen M, Senkal M, Homan H-H, et al: Early postoperative enteral nutrition with arginine-omega-3 fatty acids and ribonucleic acid-supplemented diet versus placebo in cancer patients: an immunologic evaluation of Impact(R). Crit Care Med 1995; 23:652-659.

44. Bower RH, Cerra FB, Bershadsky B, et al: Early enteral administration of a formula (Impact(R)) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients: results of a multicenter, prospective, randomized clinical trial. Crit Care Med 1995; 23:436-449.

45. Loney LC, Norling LL, & Robson AM: The use of arginine hydrochloride infusion to assess urinary acidification. J Pediatr 1982; 100:95-97.

46. Wallace AW, Ratcliffe MB, Galindez D, et al: L-arginine infusion dilates coronary vasculature in patients undergoing coronary bypass surgery. Anesthesiology 1999; 90:1577-1586.

47. Product Information: R-GENE(R) 10 IV injection, 10% arginine hcl IV injection. Pharmacia & Upjohn Company, Kalamazoo, MI, 2003.

48. Health Canada: Health Canada advises heart patients not to use products containing L-arginine. Health Canada. Ottawa, OntarioAvailable from URL: http://www.hc-sc…. .

49. Imler M, Ruscher H, Peter B, et al: The effect of arginine in a case of recurrent hepatic coma complicating a feminizing cortico-adrenal tumor with hepatic metastasis. Sem Hop Paris 1973; 49:3183-3190.

50. Bushinsky DA & Gennari FJ: Life-threatening hyperkalaemia with arginine. Ann Intern Med 1978; 89:632.

51. Hertz P & Richardson JA: Arginine-induced hyperkalemia in renal failure patients. Arch Intern Med 1972; 130:778-780.

52. Massara F, Cagliero E, Bisbocci D, et al: The risk of pronounced hyperkalaemia after arginine infusion in the diabetic subject. Diab Metab 1981; 7:149-153.

53. Tissot-Favre A & Brette R: Effets therapeutiques dumalate d’arginine dans les cirrhoses alcooliques. Therapie 1970; 25:629-638.

54. Kattwinkel J, Agus SG, Taussig LM, et al: The use of L-arginine and sodium dicarbonate in the treatment of malabsorption due to cystic fibrosis. Pediatrics 1972; 50:133-137.

55. Dietzsch HJ, Gottschalk B, Heyne K, et al: Cistic fibrosis: comparison of two mucolytic drugs for inhalation treatment (acetylcysteine and arginine hydrochloride). Pediatrics 1975; 55:96.

56. Paton W: L-arginine-induced hypotension. Lancet 1990; 336:1016-1017.

57. Elanjian SI: Necrosis caused by extravasation of arginine hydrochloride (letter). Ann Pharmacother 1992; 26:263.

58. Tiwary CM, Rosenbloom AL, & Julius RL: Anaphylactic reaction to arginine infusion. N Engl J Med 1973; 288:218.

59. Bushinsky DA & Gennari FJ: Life-threatening hyperkalaemia with arginine. Ann Intern Med 1978; 89:632.

60. Bode-Boger SM, Boger RH, Galland A, et al: L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship. Br J Clin Pharmacol 1998; 46:489-497.

61. Tangphao O, Grossmann M, Chalon S, et al: Pharmacokinetics of intravenous and oral L-arginine in normal volunteers. Br J Clin Pharmacol 1999; 47(3):261-266.
PubMed Abstract:…
PubMed Article:…

62. Morris SM Jr: Enzymes of arginine metabolism. J Nutr 2004; 134(10 Suppl):2743S-2747S.
PubMed Abstract:…
PubMed Article:…

63. Smith SD, Wheeler MA, Foster HE Jr, et al: Improvement in interstitial cystitis symptom scores during treatment with oral L-arginine. J Urol 1997; 158:703-708.

64. Smulders RA, Aarsen M, Teerlink T, et al: Haemodynamic and biochemical responses to L-arginine and L-lysin infusions in normal subjects: L-arginine-induced vasodilatation cannot be explained by non-specific effects of cationic amino acids. Clin Sci 1997; 92:367-374.

65. Cryer P, Jacobs L, & Daughaday W: Regulation of growth hormone and prolactin secretion in patients with acromegaly and/or excessive prolactin secretion. Mt Sinai J Med NY 1973; 40:402-413.

66. Schellong SM, Boger RH, Burchert W, et al: Dose-related effect of intravenous L-arginine on muscular blood flow of the calf in patients with peripheral vascular disease: a H(2)(15)O positron emission tomography study. Clin Sci 1997; 93:159-165.

67. Wolf A, Zalpour C, Theilmeier G, et al: Dietary L-arginine supplementation normalized platelet aggregation in hypercholesterolemic humans. J Am Coll Cardiol 1997; 29:479-485.

68. Heys SD, Segar A, Payne S, et al: Dietary supplementation with L-arginine: modulation of tumour-infiltrating lymphocytes inpatients with colorectal cancer. Br J Surg 1997; 84:238-241.

69. Paulus WJ, Kastner S, Vanderheyden M, et al: Myocardial contractile effects of L-arginine in the human allograft. J Am Coll Cardiol 1997; 29:1332-1338.

70. Tentolouris C, Tousoulis D, Toutouzas P, et al: Effects of acute L-arginine administration in coronary atherosclerosis (letter). Circulation 1999; 99(12):1648.

71. Nair NPV, Lal S, Thavundayil JX, et al: Effect of normal aging on the prolactin response to graded doses of sulpiride and to arginine. Prog Neuro-Psychopharmacol Biol Psychiat 1985; 9:633-637.

72. Gianotti L, Alexander JW, Pyles T, et al: Arginine-supplemented diets improve survival in gut-derived sepsis and peritonitis by modulating bacterial clearance: the role of nitric oxide. Ann Surg 1993; 217:644-654.

73. Loche S, Carta D, Muntoni AC, et al: Oral administration of argine enhances the growth hormone response to growth hormone releasing hormone in short children. Acta Paediatr 1993; 82:883-884.

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76. Boger RH, Bode-Boger SM, Thiele W, et al: Restoring vascular nitric oxide formation by L-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. J Am Coll Cardiol 1998; 32(5):1336-1344.

77. Rahim A, Toogood AA, & Shalet SM: The assessment of growth hormone status in normal young adult males using a variety of provocative agents. Clin Endocrinol 1996; 45:557-562.

78. Raiti S, Davis WT, & Blizzard RM: A comparison of the effects of insulin hypoglycemia and arginine infusion on release of human growth hormone. Lancet 1967; 2:1182-1183.

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looking up 

And if you’re white, these drugs can make you feel like an albino. It’s a drug side effect called photosensitivity. Let me explain.

I’m a brown person and I never wear sunscreen except on my face to avoid wrinkles. I worry more about osteoporosis and vitamin D deficiency instead of skin cancer and sunburns. My skin is strong and amazing, but one strange day after playing in the water all day …my arms, back, shoulders, and legs started to burn. It was an itchy, prickly feeling. Then a few days later my skin started to flake and fall off. At first I didn’t know what was happening to me. I thought the gods were getting revenge because I’d made fun of my honky relatives who burn to a crisp. “What’s happening to me,” I thought. “I’m turning into a white person. This hasn’t happened since I was a kid.”

I would burn as a kid, but as I got older my skin got tougher….that was until I started taking a new drug that caused photosensitivity.

So I just want to warn everyone, if you are put on a drug that is on the list below, you might want to be extra diligent about using the sunscreen. And if you have a child on one of these drugs, be extra careful.

Photosensitivity doesn’t always happen while on these drugs, but it’s a possibility I think you should be aware of. The following list is NOT all-inclusive. There are many other.

Common Pills that can cause photosensitivity: this list is not all-inclusive.


pyridoxine (vitamin B6) and vitamin A

bitter orange, chlorella, dong quai, gossypol, gotu kola, st john’s wart

tacrolimus, minoxidil,

Antihistamines like zyrtec, benadryl, claritin, phenergan,

Antibiotics like cipro, levoquin, avelox, noroxin, floxin, tetracycline, azithromycin, flagyl, bactrim, azulfidine,

Antifungals like terconazole, Vfend

Antivirals, like norvior, fortovase, hivid

antimalaria drugs like plaqueil,

amantadine, zofirax, methotreate, plavix, clopidogrel

water pills aka diuretics: hydrochlorothiazide, lasix, triamterene,

blood pressure drugs: captopril diltiazem enalapril nifedipine,

Cholesterol drugs: statins,

amiodarone, carbamazepine, lamotrigine, topiramate, valproic acid, thaldol,, zyprexa, risperidone, paxil, sertralin, wellbutrin, xanax, chlordiazepoxide, ambien

tricyclic antidepressants

serotonin reuptake inhibitors

All NSAID, iburprofen and naproxen

hormonal drugs, estrogens, birth control pills, testosterone

corticosteriods like prednisone

diabetic agents like glucotrol, diabeta, micronase, glipizide, amaryl





If you have been reading my blogs you know that I believe all drugs are both good and bad depending on the situation. This is true for tylenol (also known as acetaminophen), and motrin(also known as ibuprofen). And you also may know that my belief is that drugs are not dangerous….it’s drug IGNORANCE that is dangerous. Tylenol and motrin can be obtained withOUT a prescription, so don’t put yourself in one of these dangerous drug situations.


Tylenol is processed through the liver.  Daily high doses of tylenol can damage the liver (more than 3 grams), especially if the person drinks a lot of alcohol or has a weakened liver from disease. If you have been diagnosed with hepatitis C, or if you drink more than 4 times a week….you might want to switch to Ibuprofen, that would be a better choice.


Tylenol over doses are the leading cause of acute liver failure in the United States, however, half of them are intentional overdoses. Don’t be part of that group that accidentally overdoses on them. Safe doses are less than 3 grams, but for short periods of time you can go up to 4 grams if needed. Be sure to look for hidden tylenol in cold/flu products, sleep aids, menstrual cramp products etc….and add that amount to the daily dose you consume.


Now on to Ibuprofen. Ibuprofen is stronger than tylenol because it also stops swelling and redness. It’s an anti-inflamitory. It even stops the redness and swelling of a sunburn…FYI. The trade off is that unlike tylenol, there are 3 major things that can wrong here, not just one.


First:Ibuprofen is processed through the kidneys, therefore other drugs that act on the kidneys can react badly with ibuprofen. Example, the ACE inhibitors like lisinopril, Zestril, ramapril, enalapril, ….anything that ends in an “il”


These drugs lower the blood pressure in the body and in the kidneys. When the blood pressure in the kidneys goes from high to normal, the kidneys are preserved and they stay young and healthy. However, when the blood pressure in the kidneys goes from normal to LOW, that is a recipe for kidney injury, and that can happen to a person on ace inhibitors who get sick.


When a person on ace inhibitors becomes dehydrated and sick, the blood pressure in the kidneys can go too low and start damaging the kidneys. If you add ibuprofen to the mixture, things go get even worse. It’s almost like the perfect storm developing. Then if the person is also on a water pill like hydrochlorothiazide….it can accelerate the damage even more. If you are on ace inhibitors to control your blood pressure, tylenol is a better choice for you.


Occasionally we admit people to our hospital that are in acute kidney failure for this reason. It’s something to be very aware of if you take blood pressure medications.


Which reminds me…..both tylenol and ibuprofen can increase blood pressure in people who are prone to high blood pressure. You might want to monitor your blood pressure daily to make sure you stay in the safe range. I don’t know how this happens, all I know is that it does happen. Tylenol (rarely) and motrin (more often) can partially stop blood pressure medications for working properly.


Second thing that can go wrong: your stomach and intestines can bleed from ibuprofen use. Ibuprofen, and all NSAID’s (aleve, naproxen), can irritate and erode the lining of the stomach causing an ulcer or sore that can bleed. Some people have reported passing blood in their stool after just one dose. Usually it takes several doses to erode the lining. However, people who have a strong, healthy, intact stomach and intestines don’t seem to have any problem at all.


Third thing that can wrong: Soon after taking ibuprofen you can have heart attack. Usually it’s people who are on the verge of a heart attack anyways, that end up having problems. People with healthy hearts and veins don’t seem to be at risk. I wrote a blog about this and an herbal alternative that works great However, tylenol and naproxen are better choices in this situation.


I hope you have enjoyed this blog. Stay tuned for more advice on how to stay safe and healthy.








Bad Medical Advice

July 11, 2014 — 1 Comment

bad medical advice

If you are the type of person that believes in ufo’s, alien abductions, psychics, big foot etc…. you might not require a lot of medical evidence before trying herbal and alternative medications. But as a medical professional, I would lose my reputation by recommending stuff that didn’t work. I must require a high level of evidence. The highest level of evidence is called a met-analysis of randomized placebo controlled studies and the lowest level is an observational study.

My biggest pet peeve is when people who require very little medical evidence make recommendations to the general public who are easily confused and mislead. Beware of such bad advice. Here are some examples of bad advice.

Most common bad medical advice I see on the internet is recommending that someone treat a disease with herbal medicines.

If you have, or think you have, a disease that is getting worse and progressing….like prostate disease, glaucoma, cancer, infection….you need to go to a real medical doctor to stop the destriction of your body. You need treatment that is proven in the medical studies to work and work fast. You need a product that yields consistent results and that is tested and standardized.

In my opinion, the only time it is okay to treat yourself with herbal medications is to ease your discomfort when you know the source of the discomfort and that is being addressed. For example, it’s okay to take turmeric or curcurmin for arthritis pain caused from old age or an old injury. In fact it works very well, and it’s proven in the medical literature to work better than even some prescription drugs. And it’s safer. I know a good thing when I see it and I will tell you.

It’s also okay to use ginger to treat nausea and it’s okay to take probiotics for stomach upset and/or diarrhea… long as you are not delaying treatment for a serious condition.

But it is not okay to use saw palmetto to treat urinary problems. Saw Palmetto was shown in randomized trials to work by the placebo effect…even at very high doses… doesn’t work and you can delay treatment for prostate cancer if that is what is really going on.

It’s also not okay to treat cancer with herbs….I have links in my twitter account with articles to treat skin cancer with herbs. Really? The cancer could be spreading like wild-fire while you are taking herbs that have the potential to be nothing more than grass clippings sold by con artists.

However, I do believe in the possibility of miracles. Especially miracles created from a strong and healthy mind. Louise Hay writes about them and so do other people. I believe that they are possible, and I would recommend you pursue those avenues at the same time you receive traditional medical treatment. But I would NEVER recommend delaying traditional medical treatment from a medical doctor.

And just to let you know, we use about 20 dietary supplements in the hospital and they do have a place in keeping us strong and healthy under the right circumstanses. I’ll let you know what those are in my book.

Second pet peeve, do not stop taking the medications your doctor has prescribed, especially medications for diabetes or high blood pressure. If you have high blood sugar or high blood pressure you are aging at an accelerate rate. If you stop your medications you most certainly will shorten your life. But it is okay to make dietary and lifestyle changes to cure and treat those diseases. Just don’t stop taking your medications until your doctor has given you the official “okay”. Usually you must sustain your radically new and strict lifestyle for several weeks or months before it’s okay.

Third pet peave :beware of probiotics. Yogurts are good, but the supplements can be a waste of your money if you don’t get the right ones. A con artist can put powdered milk in gelatin capsules and make general claims to boost your immune system and keeps you healthy. Those words mean nothing. No one would ever know if they were not working.

The only probiotics I recommend are the ones that appear in my medical studies and I recommend them for those specific purposes. I don’t recommend them for general health. I recommend whole food and like yogurt, an orange, a salad…but NOT probiotic supplements. Reason being, everyone’s gut bacteria is different. If I went to Mexico I would get sick from their common bacteria. What is healthy bacteria for them is not healthy for me. It’s the same with probiotics. Probiotics are live bacteria that live in our intestines. Each specific type of bacteria performs a specific action and that is why they are not interchangeable.

Just for the record: Only two probiotics have been proven to cause weight loss and they are not on the market as of this date. You canNOT substitute a random probiotic and expect to lose weight. We are dealing with specific bacteria that produce a specific effect when they live in the intestines.

Two or three probiotics have been proven to boost the immune system. They were given to children in daycare who were constantly sick and that’s how the know they work. But not all probiotics across the board boost the immune system. You can read my past blog on boosting the immune system to find out which ones work.

If you want a probiotic to prevent diarrhea associated with antibiotic use you need to use lactobacillus and or saccromyces.

The probiotics claim-to-fame is the lactobacillus probiotics made famous by yogurts. These live bacteria secrete lactic acid and change the pH of the skin and environment thus preventing yeast infections. (But frozen yogurts don’t work because the probiotics are frozen/dead…fyi)

Sometimes probiotics can be inactivated by freeze-dry method and brought back to life with the addition of water. But they have to be alive to work. Which is my pet peeves number 4. If anyone recommends you take frozen yogurt or frozen kefir as a source of probiotics, then they don’t understand how probiotics work. Don’t listen to them. Dead probiotics do not work. They have to be alive and plentiful. Which reminds me, don’t waste your money on discounted or sale probiotics. They are usually old and half dead.

Bad medical advice is more prevalent than you realize, and it’s usually given out by sales people and people eager to believe anything. Beware and keep in touch.




I’ve researched a lot of near death experiences and those who have experienced both life and death say that dying is easy, living is hard. And unfortunately, I believe that even thought I don’t want it to be that way.


Waking up everyday, going to work in rush hour traffic. Dealing with annoying people. Giving your love to the people around you and not being appreciated. The list goes on of things that can wear you down and make you want to curl up into a ball and stay in bed, or even worse….do illegal drugs and or alcohol.


I think a lot of people do drugs and alcohol to escape reality. And I do not judge them, I want to help them. 


At work in the hospital I sometimes sit in a room with social workers and over-hear the social circumstances of the patients. It’s heart breaking. Many of them are sick and dying because of illegal drugs and alcohol. They are young (40’sand 50’s) and they have children that still need them. It’s a sad situation for everyone involved.


From excessive alcohol use people develop hemorrhages and bleed from their throats and intestines. Their livers become enlarged and their bellies painful and swollen. In the end stages of cirrhosis they turn yellow and their minds go delirious.


I’ve seen a young female abuse narcotic pills to the point that her intestines died and they had to be cut out. Now she poops from a hole in her stomach.


Almost all IV drug abusers end up with bacterial infections in their blood. The infections destroy the heart valves and other random parts of their body. One lady had an infection in her eyeBALLs and they had to take her to surgery multiple times to put needles into her eyes and inject antibiotics. I don’t know what happened to her, but I’m afraid she went blind.


Another young man in his 20’s has a chronic infection in his prostate. He lives with chronic pain and swelling around his anus.


But the sadest story was a young man in his twenty’s that had to be put on hospice. He was sent home to die a quiet death because his heart valve got infected. They cut it out and put a new one in. He kept doing iv drugs and the new valve got infected and destroyed. There was no tissue lift to sew a new heart valve onto. So he was sent home to die. His family was devastated.


But it doesn’t have to be that way. There is help for those people. It can come in the form of antidepressants pills.


I’ve seen and heard a lot of people bash prescription pills and antidepressants. But antidepressants can help people and change lives. They can give hope to the hopeless. They can help people keep living and keep giving their all until their circumstances change.


Because it is true that antidepressants don’t fix your personal problems. But they can give you the strength to wake-up and resolve your problems and create a better life for yourself. They can give you strength to hold down a job, sustain relationships, or take care of your children.


Even antianxiety (valium like drugs) and narcotics have their place in medicine. If someone is physically addicted to heroin or some other substance, it’s better to be on a prescription drug than street drugs….until the addiction can be resolved.


All drugs are booth good and bad depending on the circumstances. Beware of people who say all antidepressants are bad or all pain pills are bad or all valium-like drugs are bad. They are not. They are a safety net and a crutch for people who are sick and need them. And there is no shame in being sick and needing drugs. The shame comes from being stubborn and unwilling to change and improve your life. The meaning of life is to live and learn. We all have different lives, just like books and movies are different. We are experiencing different story-like lives and we should NOT compare our lives to those around us.


What complicates life is that our “happy hormones” in our brains can dry up with age, disease or pregnancy. I don’t care how wonderful you are as a person, if this happens to you, you’re going down. The quality of your life will decline, your relationships will suffer.


Dr. Amen, a brain specialist who wrote the book “Magnificent Brain” talks about doing brain scans and brain imaging on people with dementia and other diseases. Sometimes dementia is cured with giving an anti-depressant and then the person is restored to their usual self. I was amazed to read that he can physically see with a brain scan who needs anti-depressants.


Dr Amen opened my eyes to the fact that there are physical causes to needing anti-depressants. It’s not just personal problems that lead people to take antidepressants.


Please don’t self medicate with drugs and alcohol. You’ll only end up hurting yourself and your relationships. Instead, go to your doctor and ask for an antidepressant, then you can work on putting your life back together. Exercise to restore your brain chemistry, get connected with people and form relationships, join groups that interest you. Read self-help books to start healing your life. Do what is right and good. Purposefully make and create your dream life. You can have the wonderful life that you want. There is so much help out there.


In my book I write about a drug that is used to help people stop abusing their bodies. It’s a special antidepressant that restores multiple chemicals in the brain. It’s been tested to be good for people with bulimia, cocaine addictions, and smoking addictions.


This blog is already too long. I’ll have to tell you about this special drug in a future blog so please stay tuned….subscribe. Or buy my book when it comes out.








If any pill has the potential to improve the appearance of your skin it’s going to be vitamin C….in my opinion. It is essential for collagen syntheses. Collegen is connective tissue and the substance that makes skin look plump and full. In the presence of vitamin C deficiencies people develop wounds that do no heal properly. Healing is rapidly achieved when the deficiency is corrected.


In addition to having the potential to increase the thickness of the skin, vitamin C also has the potential to unify the skin color. Some experts categorize it as a skin bleach….wikipedia.


Vitamin C is the substance that keeps fruits and vegetables from tarnishing and becoming discolored when cut open and exposed to air. It’s a complicated process called biochemistry, but basically vitamin C donates an electron to atoms and molecules in desperate need of one. And for that reason, vitamin C enhances the absorption of iron from the stomach into the blood stream. Very important for people with iron deficiency anemia and blood loss.


Vitamin E is another pill with the potent to improve the skin. Similar to vitamin C, it prevents the discoloration and deterioration of meat. It is applied to meat sold in the grocery stores and keeps the produce pink and fresh looking. Without it the meat would turn a bluish gray.


Vitamin E is also added to fish oil capsules to prevent the oil from becoming rancid.


So it may came as no surprise that many topical skin products contain vitamin C and E. And there are studies proving their goodness, especially vitamin C.


But what would happen if you took these vitamins in a pill form?


Well, there are two studies that tested both these pills together short term and the results were astounding to me. Taking a combination of both vitamin C and vitamin E supplements ORALLY 2 grams of vitamin C along with 1000 IU oral vitamin E before sun exposure, reduced skin inflammation after sun exposure.4715,4716


Could these pills prevent photo aging? Possibly, since the main source of skin damage is from the sun, it makes sense, but I wouldn’t use these pills in place of sunscreen.


However, there are some commercially available products on the market that claim to be sunscreen in a pill. Basically they are combinations of vitamins C, E and A. If you don’t know it yet, vitamin A is dangerous and should only be prescribed by an eye doctor or skin doctor because it caused cancer in smokers. However, it is good for the skin and eyes. That’s another blog….subscribe and I’ll explain later.


There is also a new an antioxidant pill made from a fern that protects from the sun. It’s called Heliocare and we are still discovering how it works and what side effects it has.


But I would caution people that these pills have consequences. Vitamin C in high doses can cause nausea, vomiting, diarrhea and kidney stones. Vitamin E has been linked to an increase in prostate cancer and hemorrhagic strokes. But lots of people are willing to take their chances in pursuit of beauty, and I totally understand that. If you’re that kind of person you might also want to look into DHEA. DHEA is a pill and has been studied in relation to improving the skin and I will reveal those studies in a future blog along with much more. Stay tuned. Subscribe!



Topical Vitamin C: Traikovich SS. Use of topical ascorbic acid and its effects on photodamaged skin topography. Arch Otolaryngol Head Neck Surg. 1999;125:1091-1098.



Fuchs J, Kern H. Modulation of UV-light-induced skin inflammation by D-alpha-tocopherol and L-ascorbic acid: a clinical study using solar simulated radiation. Free Radic Biol Med 1998;25:1006-


Eberlein-Konig B, Placzek M, Przybilla B. Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-alpha-tocopherol (vitamin E). J Am Acad Dermatol 1998;38:45-